- a bit of a bother.
- as the intensity increased the sensation changed from tickle to pain.
- he's not a friend, he's an infliction.
- It pains me to see my children not being taught well in school.
- that kid is a terrible pain.
- the pain of loneliness.
- the patient developed severe pain and distension.
- washing dishes was a nuisance before we got a dish washer.